El famoso director contará con un elenco estelar que incluye a Emily Blunt (Katherine Oppenheimer), Matt Damon (Leslie Groves), Robert Downey Jr. (Lewis Strauss), Florence Pugh (Jean Tatlock), Rami Malek, Benny Safdie (Edward Teller), Josh Hartnett (Ernest Lawrence), Dane deHaan, Jack Quaid, Matthew Modine, Dylan Arnold (Frank Oppenheimer), Olli Haasviki, Alden Ehrenreich, David Krumholtz, Michael Angarano (Robert Serber) y Kenneth Branagh.
